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VCs investing in SaaS
A curated list of active US VCs investing in SaaS startups worldwide.

Today, we selected 20 active US VCs from our database, investing in SaaS startups.
Our team reviewed, checked, and enriched the list with the necessary data.
(The first 10 are free for all subscribers, the last 10 are open to our premium subscribers.)
Here goes:
• 46 Venture Capital — Based in Tulsa, 46VC is an early-stage VC firm investing in AI, ML, and SaaS startups. They collaborate with universities and regional networks to support groundbreaking technologies and foster innovation in underserved markets through their multi-fund platform.
• 165 Ventures — Located in Steubenville, 165 Ventures is a Seed-stage VC backing AI, ML, and SaaS companies. The firm invests in visionary founders guided by strong ethical values, aiming to reshape industries with purpose-driven innovation and leadership.
• 280 Capital — Based in New York, 280 Capital is the Web3-focused investment arm of the Huang, Liu, and Chen Family Office. With deep roots in digital assets, they invest in AI, blockchain, cryptocurrency, SaaS, and Web3 ventures to advance decentralized innovation.
• 412 Venture Fund — Pittsburgh-based 412 Venture Fund supports SaaS startups at Pre-seed to Series A stages. Backed by experienced entrepreneurs, they provide capital and expertise to help early-stage companies accelerate growth and navigate key milestones.
• 500 Global — Headquartered in San Francisco, 500 Global is a prominent early-stage VC firm with $2.7B AUM. They invest in Seed and Series A SaaS startups globally, offering capital, resources, and an international network to over 2,600 companies in 80 countries.
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• 500 Startups — Based in San Francisco, 500 Startups is a Pre-seed VC firm investing in global SaaS founders. As one of the world’s most active venture capital firms, they focus on identifying top entrepreneurial talent and helping them scale with speed and support.
• 640 Oxford — 640 Oxford is a New York-based Pre-seed and Seed-stage VC firm investing in AI, ML, and SaaS. Sector-agnostic, the firm backs highly motivated founders early in their journey, offering operational guidance and collaborative capital.
• 1843 Capital — Located in Greenwich, 1843 Capital invests in early-stage SaaS, cybersecurity, wellness, and healthcare companies. The firm focuses on the AgeTech and Longevity sectors, backing innovative solutions across defense, fintech, and transportation.
• 1855 Capital Partners — Based in State College, 1855 Capital is a Seed-stage VC firm investing in SaaS companies with a Penn State University connection. They leverage university research and alumni networks to uncover promising innovation.
• 1955 Capital — Located in Los Altos, 1955 Capital backs early-stage companies in AI, ML, and SaaS. The firm partners with entrepreneurs tackling global challenges and aims to commercialize advanced technologies with high-growth market potential.
That’s all for today. Have a great day!
Tzakhi
Founder of InvestorsLists.VC and Meet.Capital

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