US Series-A VCs investing in AI/ML

Today, we selected 20 active US Series-A VCs from our database, investing in AI/ML startups.  

Our team reviewed, checked, and enriched the list with the necessary data.

(The first 10 are free for all subscribers, the last 10 are open to our premium subscribers.)

Here goes:

• 11.2 Capital — Based in San Francisco, 11.2 Capital is an early-stage VC fund investing in companies with breakthrough technologies. They focus on sectors such as AI, healthcare, security, and smart hardware, backing founders developing data-driven therapeutics, diagnostics, robotics, AR/VR, and enterprise software with a global vision.

• 20SALES — San Francisco-based 20SALES is a VC fund investing in early-stage B2B SaaS startups. Focused on Seed and Series A, they position themselves as the ideal $100K+ check on the cap table for high-performing founders, offering a significant boost in a startup’s chances of success.

• Acario — Located in Menlo Park, Acario is a venture firm powered by Tokyo Gas, focused on investing in sustainability, new energy, and climate-related startups. With a Series A focus, Acario backs founders innovating in clean energy, SaaS, and AI to drive the energy transition forward.

• Access Industries — Headquartered in New York, Access Industries is a globally active VC with investments spanning media, biotech, SaaS, and real estate. They participate in Seed and Series A rounds across sectors, leveraging long-term holdings and a diversified strategic approach.

• Acorn Pacific Ventures — Based in Santa Clara, Acorn Pacific Ventures is an early-stage VC focused on B2B enterprise, supply chain, healthcare, and SaaS companies across North America and APAC. They invest at Seed and Series A stages, helping to scale companies in industrial and healthcare innovation.

• age1 — San Francisco-based age1 invests in early-stage ventures developing therapeutics and technologies aimed at healthy lifespan extension. They focus on biotech, healthcare, AI, and SaaS solutions targeting aging and age-related diseases, backing companies from pre-seed through Series A.

• AI Capital — Headquartered in Parker, Colorado, AI Capital targets enterprise AI software companies in industries like AgTech, manufacturing, cybersecurity, and healthcare. They invest from Seed to Series B, focusing on AI solutions driving societal impact through enhanced productivity and public safety.

• AI Fund — Based in Palo Alto, AI Fund is a VC that partners with entrepreneurs from inception to Series A, helping them solve big problems through AI. They specialize in supporting early-stage teams through company formation, product strategy, and market validation.

• AIX Ventures — AIX Ventures is a San Francisco-based VC firm investing exclusively in pre-seed and seed-stage startups powered by AI. Led by AI practitioners, the firm backs early teams building technical solutions across sectors using machine learning.

• Amplify Partners — Menlo Park’s Amplify Partners invests in technical founders at the earliest stages, backing breakthroughs in AI, ML, developer tools, and cybersecurity. Their pre-seed to Series A strategy centers on deep technical expertise and hands-on support.

That’s all for today. Have a great day!

Tzakhi

Founder of InvestorsLists.VC and Meet.Capital 

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