US Seed VCs investing in AI/ML

Today, we selected 20 active US Seed VCs from our database, investing in AI/ML startups.  

Our team reviewed, checked, and enriched the list with the necessary data.

(The first 10 are free for all subscribers, the last 10 are open to our premium subscribers.)

Here goes:

• Emerging Ventures — Los Angeles-based Emerging Ventures invests in seed-stage technology startups across the US and Canada, with a focus on AI, ML, and SaaS. The firm looks for companies with strong potential to secure significant institutional rounds within 12–24 months. Structured as a VC fund, it is open to accredited individuals, family offices, institutional investors, and advisors, providing early-stage capital to entrepreneurs using emerging technologies to solve business challenges.

• Endeavor Catalyst — New York-based Endeavor Catalyst is a rules-based, co-investment VC fund that supports Endeavor Entrepreneur-led companies at seed and Series A stages. Focused on AI, ML, and SaaS, it sustains Endeavor’s global mission while distributing returns to LPs. With over $500M AUM across four funds and more than 300 investments worldwide, the portfolio now includes dozens of unicorns, helping founders scale businesses with both capital and global infrastructure support.

• Executive Ventures — United States-based Executive Ventures is a seed-focused VC firm specializing in AI and ML. It invests in entrepreneurs applying deep machine learning, IoT, and actionable big data analytics to real-world problems. Alongside capital, the firm provides strategic advice and insights to both founders and investors, supporting bankable opportunities with long-term growth potential. Its approach combines early financing with guidance to help startups turn advanced technology into commercially viable solutions.

• Faction — Menlo Park-based Faction is a VC firm investing in disruptive crypto projects from seed through Series A. With a vertical-agnostic approach, it backs entrepreneurs working across blockchain layers, DeFi, NFTs, and SaaS. Its thesis emphasizes the seismic long-term impact of crypto, combining flexible equity and token investments. Faction partners with founders building practical blockchain utilities, aiming to push the frontier of Web3 innovation while maintaining a strong conviction in early-stage, AI and ML-enabled ecosystems.

• Figment Capital — Nyack-based Figment Capital is a venture firm investing in early-stage blockchain infrastructure, with additional focus on AI, ML, Web3, and security. Launched in 2021, the fund works closely with founders from idea through adoption, drawing on its deep connection to Figment Inc. This relationship provides technical expertise and credibility within the crypto industry. The team emphasizes security and long-term utility, partnering with entrepreneurs to build foundational Web3 infrastructure and scalable SaaS solutions.

• First In Ventures — Middletown-based First In Ventures is a seed-stage biotech venture capital firm at the intersection of genomics and data science. The firm invests in AI- and ML-enabled biotechnology and fintech innovations, providing both initial and follow-on capital. With industry expertise and operational support, it helps early-stage companies navigate complex science and business challenges. By focusing on transformative technologies, First In Ventures seeks to back entrepreneurs building the next generation of data-driven biotech breakthroughs.

• Forward Deployed VC — San Francisco-based Forward Deployed VC is a seed-stage firm focused on defense, energy, manufacturing, and mission-critical SaaS sectors. Backed by Bain Capital Ventures and 100+ operators from Palantir and Anduril, it brings expertise across hacking, machine learning, nuclear engineering, and government contracting. The firm emphasizes deep AI and ML applications, supporting entrepreneurs tackling national and industrial challenges. Its operator network provides strategic, technical, and financial guidance to founders solving high-stakes global problems.

• Frontier Ventures — Cupertino-based Frontier Ventures is a VC firm investing in early-stage AI and ML startups, particularly those with strong network effects. With a global outlook, it partners with entrepreneurs building SaaS and intelligent platforms positioned for international growth. The fund emphasizes supporting founders who aspire to build market-leading businesses, offering both capital and strategic guidance. Its mission is to enable entrepreneurs to leverage AI-driven technologies to scale globally competitive companies from the early stages.

• GBIC — New York-based GBIC, or Global Blockchain Innovative Capital, is a VC firm investing at seed and Series A in blockchain, crypto, AI, ML, and SaaS startups. The fund positions itself as a global hub for blockchain innovation, emphasizing strategic investment, community building, and strong partnerships. GBIC accelerates project development and market adoption by leveraging its international network. Its thesis is rooted in advancing blockchain technology while supporting entrepreneurs building scalable and disruptive digital platforms.

• Ginossar Ventures — New York-based Ginossar Ventures is a seed-stage VC investing in B2B SaaS companies with applications in fintech, cybersecurity, and healthcare. With a focus on AI, ML, and security technologies, it partners with leaders positioning their businesses for traction and scale. The firm emphasizes sustainable, long-term success by supporting early-stage founders with both capital and strategic guidance. Its approach targets companies solving complex challenges across finance, digital health, and enterprise technology infrastructure.

That’s all for today. Have a great day!

Tzakhi

Founder of InvestorsLists.VC and Meet.Capital 

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