US seed accelerators

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Today, we selected 10 active USA accelerators from our database, investing in seed startups.  

Our team reviewed, checked, and enriched the list with the necessary data.

Here goes:

• MassChallenge — Based in Boston, MassChallenge is a nonprofit accelerator connecting startups, experts, and corporations to drive economic transformation. Its equity-free model enables seed-stage SaaS startups from diverse backgrounds to scale bold, disruptive ideas. Through a global network of programs and mentorship, MassChallenge empowers founders to innovate with impact and build sustainable, high-growth ventures.

• MetaProp — Located in New York, MetaProp runs the world’s leading PropTech accelerator at Columbia University. Focused on fintech and real estate technology, the program supports early-stage founders developing innovative property solutions. By combining academic collaboration and venture expertise, MetaProp helps entrepreneurs transform the global real estate ecosystem through digital acceleration and strategic mentorship.

• mHUB — Chicago-based mHUB is the United States’ premier hardtech and manufacturing accelerator. Since 2017, it has helped startups launch over 1,500 products and raise more than $1.5B. Focused on hardware, manufacturing, and industrial SaaS, mHUB provides mentorship, R&D facilities, and capital access to ensure America’s manufacturing innovation continues to grow and thrive.

• NMotion — Based in Lincoln, NMotion powered by gener8tor is Nebraska’s first accelerator program, founded in 2013. It invests $100K in early-stage, high-growth startups across the Midwest. Focused on fostering innovation in regional markets, NMotion connects entrepreneurs to mentors, investors, and resources through its intensive 12-week accelerator program run twice annually.

• OneSixOne Ventures — Located in Gainesville, OneSixOne Ventures is an accelerator and VC firm investing in pre-seed and seed-stage GovTech and B2B SaaS startups. The firm focuses on technology solutions that improve government efficiency and enterprise operations. Through mentorship and capital, OneSixOne helps founders refine their products and achieve scalable market traction.

• PLUS9 — Based in Los Angeles, PLUS9 is a seed-stage accelerator focused on SaaS startups. The program provides funding, mentorship, and strategic network access to help founders grow their businesses. Emphasizing collaboration and long-term relationships, PLUS9 invests both capital and time to guide startups through their acceleration journey and beyond.

• Project Skyway — Minneapolis-based Project Skyway is Minnesota’s first seed-stage accelerator for tech entrepreneurs. It builds strong connections among founders, mentors, and investors while promoting ethical, long-term business practices. The program supports startups developing sustainable, impactful technologies through mentorship and community collaboration, driving regional innovation.

• Prosper HealthTech Accelerator — Headquartered in Madison, Prosper HealthTech Accelerator supports seed-stage healthcare startups. It connects founders with healthcare leaders to co-innovate transformative solutions. Through mentorship and investment, the program helps startups addressing major health challenges scale their technologies and drive systemic improvement in patient outcomes and healthcare delivery.

• SEED SPOT — Based in Phoenix, SEED SPOT is a nationally ranked social impact accelerator supporting diverse entrepreneurs. Through programs like Impact Accelerator and Launch Camp, it helps founders build ventures tackling global challenges. Recognized for empowering underrepresented founders, SEED SPOT provides education, investment, and mentorship to foster inclusive innovation worldwide.

• Silicon Catalyst Angels — Located in Santa Clara, Silicon Catalyst Angels is an accelerator and investment network focused on hardware and semiconductor startups. Formed in 2019, it connects early-stage founders with seasoned industry veterans. The group leverages deep sector knowledge, capital, and mentorship to accelerate the next generation of hardware and fintech innovation.

We also put together a list of 200 active USA-based VCs investing in series-A startups.

Our premium subscribers can access the list with all of the necessary data, including:

Name, website, HQ location, LinkedIn company page, description/thesis, preferred stages, preferred domains, and contact email.

That’s all for today. Have a great day!

Tzakhi

Founder of InvestorsLists.VC and Meet.Capital 

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