San Francisco Series-A VCs

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Today, we selected 10 active San Francisco Series-A VCs from our database, investing in startups.  

Our team reviewed, checked, and enriched the list with the necessary data.

Here goes:

• Astia — San Francisco–based Astia is a venture capital firm investing at the A-round stage in high-performing companies. Using its proprietary Expert Sift™ methodology, it applies data-driven, bias-free screening to identify exceptional founders, with a strong commitment to supporting women of color and addressing intersectionality in entrepreneurship.

• Atacama Ventures — Based in San Francisco, Atacama Ventures is an early-stage VC firm supporting big ideas, future brands, and the next generation of fund managers. Focused on consumer products and services, it partners with founders redefining their categories through creativity and innovation.

• Autism Impact Fund — San Francisco’s Autism Impact Fund invests in life sciences and therapeutics, focusing on innovations that improve life beyond childhood. This A-round venture fund backs companies developing breakthrough solutions for individuals with autism and their families.

• Baruch Future Ventures — San Francisco–based Baruch Future Ventures is a VC and family office fund investing at the A-round stage. It focuses on climate-sensitive innovations across clean energy, renewables, healthcare, food, and air technologies that drive sustainability and healthier living.

• Breakout Ventures — Operating from San Francisco, Breakout Ventures backs creative bioscience entrepreneurs in healthcare and climate. The firm invests early and supports founders from seed to scale, helping science-driven startups harness cellular power for human and environmental impact.

• Buckley Ventures — San Francisco’s Buckley Ventures partners with entrepreneurs building ambitious technology companies. As a venture capital firm investing at the A-round stage, it focuses on long-term relationships and helping founders realize transformative visions in the tech sector.

• Burnt Island Ventures — Based in San Francisco, Burnt Island Ventures is a venture capital firm specializing in water sector innovation. Known for its deep founder support and extensive industry network, the firm invests at the A-round stage in startups reshaping global water management.

• Caffeinated Capital — San Francisco–based Caffeinated Capital partners with founders at the inception stage. This A-round venture firm focuses on technology startups, backing ambitious entrepreneurs from day one to build enduring and category-defining companies.

• Canonical Crypto — Operating from San Francisco, Canonical Crypto is a venture capital firm investing at the A-round stage in early crypto infrastructure. It supports founders building foundational blockchain technologies shaping the next generation of decentralized systems.

• Chamaeleon — San Francisco–based Chamaeleon is an early-stage VC firm applying a full-stack technology approach to venture investing. The firm builds its own VC technology platform to enhance sourcing and due diligence, driving innovation in how early-stage startups are funded and supported.

We also put together a list of 200 active USA-based VCs investing in series-A startups.

Our premium subscribers can access the list with all of the necessary data, including:

Name, website, HQ location, LinkedIn company page, description/thesis, preferred stages, preferred domains, and contact email.

That’s all for today. Have a great day!

Tzakhi

Founder of InvestorsLists.VC and Meet.Capital 

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